1 bottle
$79.99 a bottle
$79.99
+ $10 shipping+ $10 shipping
- About 60 days at 1 pump a day60 days
- Free US shippingFree shipping (not included)
- Bundle discountDiscount (not included)
- Lowest price per bottleLowest price (not included)
Formula 01 · 60 mL leave-on scalp serum
2DDR Scalp & Hair Serum for stronger-looking, thicker-looking hair
A lightweight, non-greasy gel for a simple daily scalp routine. Applied once a day to a dry scalp, it dries to a thin film you leave on.
Choose your supply 60 mL a bottle · up to 2 months each
Secure checkout on the official Synergy45 Shopify store
Pay with Shop Pay, Apple Pay or Google Pay at checkout.
View the 2-DDR formula that took 2 years to perfect → See how many bottles you need ↓
The routine
Stronger-looking, thicker-looking hair
1–2 pumps (about 1–2 mL) on a dry scalp, once a day. Leave it on.
The formula
Patent pending
A patent application covering the formulation and delivery approach has been filed.
The work
Two years of formulation work to get here
45 reformulations along the way. Now in a 60 mL black glass pump bottle.
Patent pending
Fragrance-free
Processed in 1 business day
Free US shipping on 2+
2 years
of focused formulation work
45
reformulations to get it right
58 → 6
actives, first draft to Formula 01
2.5%
2-DDR, the core active, stated on the label
Two years in the making
How Formula 01 was built
Drag through every stage, from the first draft to the bottle you can buy today.
Every decision, in order
STAGE1
58 actives
Testing 58 actives as partners for 2-DDR exposed the limits of conventional formulation.
Every active was graded on its evidence, including its true delivered yield. The finding: the failures were architecture, not chemistry. 58 actives became 35.
Incompatible chemical classes were separated into dedicated delivery systems, then tested.
2-DDR was pulled out and isolated in its own delivery system, built on an alginate gel.
Formulation review extended beyond the primary actives to every solvent, surfactant and stabilizer. Comedogenic esters, sensitizing surfactants and polymers prone to flaking in daily leave-ons were removed.
2-DDR in alginate, joined only by actives at established levels, and nothing that fights the gel.
One final adjustment, set by bench testing, before the formula was frozen.
Formula 01 is available now. Formulas 02–05 each get their own bottle, built the same way: one decision at a time.
Stage 1 of 8
58 actives, one bottle
Went in
- He Shou Wu (Polygonum multiflorum)Added from its traditional use.
- A lipid carrier systemAdded for slow release. It could never be made consistently.
Came out or moved
- Adenosine at more than double its usual levelBrought back down to 0.75%. More is not better.
Stage 2 of 8
The evidence audit: 58 actives down to 35
Went in
Nothing added at this stage.Came out or moved
- He Shou WuLittle support beyond traditional use, and a risk of irritation.
- KaempferolToo little of it made it into the bottle to matter.
- Soy lecithinIt was quietly weakening the preservative.
- Adenosine in a liposomeAdenosine works in a plain water-based gel. It never needed a special carrier.
Stage 3 of 8
Split by chemistry into separate bottles
Went in
- A separate bottle for copper ingredientsCopper ingredients need their own environment, away from ingredients that break them down.Formula 03
Came out or moved
- Vitamin C next to copperThe two react with each other.
- Strong mineral binders next to copperThey pull the copper loose.
Stage 4 of 8
Five separate formulas
Went in
- Alginate gelThe base of Formula 01, chosen for 2-DDR.Formula 01
Came out or moved
- 2-DDRMoved out of a fast-release gel and into the alginate gel.Moved to Formula 01
- Rinse-off ingredientsIngredients that work best rinsed off went to the shampoo.Moved to Formula 05
Stage 5 of 8
Closing the gaps: the excipient audit
Went in
- MelatoninAdded as an antioxidant partner for 2-DDR.Formula 01
Came out or moved
- Isopropyl myristateKnown to clog pores. Not something to put near the scalp.Formulas 02–05
- Cocamidopropyl betaineA known skin allergen. We accepted less foam.Formula 05
- Rosemary essential oilScent and skin-sensitivity risk.Formulas 02–05
Stage 6 of 8
Formula 01 is built and frozen
Went in
- Adenosine 0.75% + caffeine 1.5%Chosen as a pair, at established cosmetic levels.
- Niacinamide 3.0% + panthenol 1.0%Together with adenosine, a well-known trio.
- Melatonin set at 0.10%Raised 30-fold to its established level.
- Sodium phytateKeeps stray minerals from stiffening the gel and supports the preservative.
Came out or moved
- ZincIt would break down the alginate gel.
- No peptides keptThey brown when mixed with 2-DDR.
- 2-DDR at 5%More is not better. 2.5% was chosen.
- Caffeine above 1.5%No reason to go higher.
- Pentylene glycolIt competes with the gel for water.
- Popular branded hair activesEach one clashed with the gel or the preservative.
Stage 7 of 8
The last change: a stronger gel
Went in
- Alginate doubledSet by bench testing for the right texture on a dry scalp. Formula 01’s final change.Formula 01
Came out or moved
Nothing removed at this stage.
Stage 8 of 8
Formula 01 today. Four more to come.
Went in
- Formula 012.5% 2-DDR plus five supporting actives, each at a stated level, in a weightless alginate gel.Available now
Came out or moved
Nothing removed at this stage.2-DDR—
Melatonin—
Adenosine—
Caffeine—
Niacinamide—
Panthenol—
A selection of the decisions on record. Formulas 02–05 are separate products, still in development. Formula 01 is a cosmetic and is not intended to diagnose, treat, cure or prevent any disease.
Choose your supply
One bottle lasts about 60 days.
At 1 pump a day. Stock up and shipping is on us. Set your routine and we'll mark the bundle that fits.
Your routine length90 days
You need 2 bottles for 90 days at 1 pump a day.
2 bottlesSave $10
$74.99 each
- About 120 days at 1 pump a day120 days
- Free US shippingFree shipping
- $10 off ($5 a bottle)$10 off
- Lowest price per bottleLowest price (not included)
3 bottlesSave $24
$71.99 each
- About 180 days at 1 pump a day180 days
- Free US shippingFree shipping
- $24 off ($8 a bottle)$24 off
- Lowest price per bottleLowest price
Bundle prices apply automatically in the cart. Straight to secure Shopify checkout.
What's inside
Six actives. Every percentage on the label.
No token doses. Tap an ingredient to see what it's there for. Every Formula 01 ingredient →
01 of 06
2.5%
2-DDR
2-deoxy-D-ribose, the core of Formula 01, at a stated 2.5%. Carried in a weightless alginate gel built for stronger-looking, thicker-looking hair.
Why the 2-DDR concentration is 2.5% →
02 of 06
3.0%
Niacinamide
Vitamin B3, at 3.0%. One of six actives in a formula built for stronger-looking, thicker-looking hair.
03 of 06
1.5%
Caffeine
At 1.5%, paired with adenosine at 0.75%, for a revitalized-looking scalp.
04 of 06
1.0%
Panthenol
Provitamin B5, at 1.0%. Brings moisture to the scalp and the hair at the root, for stronger-looking, more resilient strands.
05 of 06
0.75%
Adenosine
At 0.75%, a level chosen deliberately, not rounded up for the label. Paired with caffeine.
06 of 06
0.10%
Melatonin
At 0.10%, the smallest of the stated active levels, completing the six.
Watery serumRuns off
Why a gel
How the alginate matrix works →
A gel, not a watery serum.
A clean sodium alginate gel that spreads into a thin film on a dry scalp and stays on between washes.
No greaseWeightless feel
No flakesDries to a film
No rinseLeave it on
The overnight ritual
Two minutes tonight. On until morning.
Once a day, on a dry scalp. Tap a step, or watch the night go by.
EveningEveningBedtimeOvernightMorning
Start with a dry scalpWater left on the scalp dilutes the gel.
1–2 pumps at the rootsAbout 1–2 mL. Part the hair and apply.
Massage into a thin filmWeightless. No grease. Do not rinse.
Stays on while you sleepThe alginate gel stays on until your next wash.
Wash as usualRinse at your next shower. Repeat once a day.
A simple 90-day routine
Using 1 pump a day for 90 days. Change it in the bottle calculator above.
Drag through your routine
DAY45
Stay consistent
Build the habit: 1–2 pumps on a clean, dry scalp. Leave it on. Take a day-1 photo.
Stay consistent: Same time, same amount. Take a photo in the same light.
Compare: Set your latest photo beside day 1 and judge for yourself.
You'll need
2
Bottles of Formula 01
120 days of serum at 1 pump a day, for a 90-day routine
15 mL
60 mL
A routine plan, not a promised result.
Does Formula 01 work?
Formula 01 is a cosmetic scalp serum made for stronger-looking, thicker-looking hair, used once a day. It is not a drug and does not treat hair loss.
What's in it? Is it fragrance-free?
Every ingredient is listed with its percentage, and Formula 01 is fragrance-free. See every ingredient → To report a reaction, email contact@synergy45.com.
Where do I buy it?
At the official Synergy45 store, shop.synergy45.com, with secure Shopify checkout.
How long does a bottle last?
About 60 days at 1 pump a day, or about 30 days at 2 pumps a day.
How fast does it ship?
Orders are processed within 1 business day and ship the next business day by USPS Priority Mail. Delivery usually takes 4–6 business days after shipping. US addresses only.
Can I return it?
All sales are final. If a bottle arrives damaged or incorrect, email contact@synergy45.com within 7 days of delivery with your order number, photos and a short video, and we ship a replacement at no cost. Refund policy →
SYNERGY45Formula 01
60 mL
Black glass pump bottle
2.5%
2-DDR plus five actives
1–2
Pumps, once a day
~60
Days per bottle at 1 pump a day
Available now
Formula 01 — 2-DDR scalp serum
$79.99
- $10 shipping on one bottle, free on 2 or more
- 2 bottles $74.99 each, 3 bottles $71.99 each
- Processed within 1 business day and shipped the next business day from California to US addresses
- Arrives 4–6 business days after shipping, by USPS Priority Mail
- All sales final. A damaged or incorrect bottle is replaced at no cost
What this product is (and is not)
It is
- It is A leave-on cosmetic scalp serum, used once a day on a dry scalp
- It is A clean sodium alginate gel with six actives at stated levels
- It is Made for stronger-looking, thicker-looking hair
It is not
- It is not A drug
- It is not A hair-loss treatment
- It is not Intended to diagnose, treat, cure or prevent any disease
The system
One product. One part of a larger approach.
Hair appearance is commonly discussed as a single concern. In reality, how hair looks and feels depends on several factors, from scalp condition to fiber strength. SYNERGY45 was built as a multi-product cosmetic system so that different products can address different aspects of scalp condition and hair appearance.
Formula 01 is available first. Formulas 02–05 will follow as each completes its own testing and preparation.
Explore the five-formula system →Formula 01 · Available now
A clean alginate gel carrying 2.5% 2-deoxy-D-ribose and five supporting actives, formulated for visibly thicker-looking, fuller-looking, denser-looking hair.
Formula 02 · Coming later
Aqueous serum for further aspects of scalp condition and hair appearance.
Formula 03 · Coming later
A liposomal concentrate for scalp condition, planned with copper ingredients. These are not in Formula 01.
Formula 04 · Coming later
Anhydrous scalp oil for actives that need an oil environment, focused on scalp comfort and the appearance of hair.
Formula 05 · Coming later
Sulfate-free scalp shampoo for everyday cleansing, made to pair with the leave-on products.
Already using Formula 01?
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Track your routine in the Synergy45 app
Formula 01 · $79.99
Free US shipping on 2+
SYNERGY45
Buy Formula 01 — $79.99
Synergy45 Formula 01 $79.99 · 2 for $74.99 each · 3 for $71.99 each · Free shipping on 2+